An Investigation into the Levels of Asprosin Hormone and Some Immunological Variables in a Number of Obese Women in the City of Kirkuk

Abstract

The current study involved examining the level of Asprosin hormone and some immunological variables, including TNF-α, IL-1, and IL-6, in 100 samples from women. These samples were divided into 50 blood samples from obese women, 30 from lean women, and 20 from women with ideal weight, all ranging in age from 25 to 45 years. The study was conducted from November 2021 to the end of April 2022. Blood samples were collected in the early morning after a minimum fast of 6-8 hours, excluding pregnant women and patients. The statistical analysis results showed a significant increase (P≤0.01) in Asprosin concentration in obese women (5.82 ± 0.83) ng/ml, compared to the control group (3.27 ± 0.40) ng/ml. However, there were no significant differences in Asprosin concentration in lean women (3.10 ± 0.22) ng/ml compared to the control group (3.27 ± 0.40) ng/ml. As for the immunological variables, the statistical analysis showed a significant increase (P≤0.05) in the concentration of TNF-α in the serum of obese women (225.13 ± 6.71) ng/L, and in the serum of lean women (155.75 ± 3.04) ng/L compared to the control group (148.41 ± 5.18) ng/L. The results also showed a significant increase at (P≤0.05) in the concentration of IL-6 in the serum of obese women (2.28 ± 3.10) pg/ml compared to the control group (0.33 ± 2.19) pg/ml, while there were no significant differences in the serum of lean women (0.92 ± 2.69) pg/ml compared to the control group. However, the statistical analysis showed a significant decrease (P≤0.01) in the concentration of IL-1 in the serum of obese women (168.06 ± 19.8) pg/ml, and in the serum of lean women (309.25 ± 13.47) pg/ml compared to the control group (420.45 ± 29.47) pg/ml.