Clinical Correlation between Vitamin K Deficiency and Matrix Gla Protein (MGP) Levels in Patients Undergoing Hemodialysis

Abstract

Chronic kidney disease (CKD) is closely linked to low vitamin K levels.  Two major consequences of chronic kidney disease (CKD) that raise the risk of death and morbidity are skeletal fragility and cardiovascular disease (CVD).  Vascular calcification (VC), alterations in bone tissue and metabolism, hormonal and ionic disorders, and chronic renal disease are all linked in a complicated pathogenetic way in CKD-MBD.  Chronic renal illness, bone issues, and cardiovascular disease appear to be significantly influenced by vitamin K deficiency.  Phylloquinone, menaquinone, and menadione are the three forms of vitamin K that are now accessible. Examined the connections between plasma vitamin K and serum total matrix G protein (MGP) in hemodialysis (HD) patients.  Methods: In a case-control study, thirty samples were taken from patients at Al-Kadhimiya Teaching Hospital who had chronic renal disease, and thirty samples were taken from healthy individuals who were in good condition and the same age and gender. Serum vitamin K levelsand Total MGP were measured using the ELISAtechnique. Using a spectrophotometer and a colorimetric test, the amounts of creatinine and urea were measured.

Results: The results showed that there was no statistical significance in age. While urea m creatinine, and vitamin K levels were high in all age groups included in the study. In conclusion, serum vitamin K levels were lower compared to the control group, and increased Total MPG in HD.