Immunological Study for Tuberculosis AmongSample of Children and Young Iraqi Patients

Abstract

Mycobacterium tuberculosis is highly successful as an intracellular pathogen that has developed strategies to survive even in the presence of high immune pressure. Blood were collected from a total of 65 patients confirm with tuberculosis(TB), who attended the Institute of Chest and Respiratory Diseases/ Medical City in Baghdad during the period between January-2026 till the end of July-2026, and 15 apparently healthy individual as control group, from both genders with age rang (1-25) year. The Immunological study was carried out toestimatethe level of TNF-α and IFN-Ɣ in patients and control group by ELIZA method using causabiokit. The effect of age and gender on TNF-α and IFN-Ɣ levels of patients were studied. The outcome ofTNF-αshowed an elevation in its value among TB patients (49.66 ± 6.24), in comparison with control group (10.952 ± 3.07),also the level of  IFN-γ in patients was found high with mean value (38.27 ± 10.82), in comparison with healthy control group (3.069 ± 0.84).it was appeared that elevation ofTNF-α and IFN-Ɣ values significantly not effected by age and gender.